An interpretable machine learning model for predicting the optimal day of trigger during ovarian stimulation

An interpretable machine learning model for predicting the optimal day of trigger during ovarian stimulation

May 16th, 2022

Michael Fanton, Ph.D. | Veronica I. Nutting, B.A. | Funmi Solano | Paxton Maeder-York, M.S., M.B.A. | Eduardo Hariton, M.D., M.B.A. | Oleksii O. Barash, Ph.D. | Louis N. Weckstein, M.D | Denny Sakkas, Ph.D. | Alan B. Copperman, M.D. | Kevin E. Loewke, Ph.D.

Abstract

Objective: To develop an interpretable machine learning model for optimizing the day of trigger in terms of mature oocytes (MII), fertilized oocytes (2PNs), and usable blastocysts.

Design: Retrospective study.

Setting: A group of three assisted reproductive technology centers in the United States.

Patient(s): Patients undergoing autologous in vitro fertilization cycles from 2014 to 2020 (n = 30,278).

DOI:https://doi.org/10.1016/j.fertnstert.2022.04.003

Ovarian Stimulation